Endocrine Abstracts

De novo lipogenesis (DNL) is recognised as potentially contributory to pathogenesis of non-alcoholic fatty liver disease (NAFLD), and could be a factor in the progression of simple steatosis to steatohepatitis, although it contributes a relatively minor amount of whole body fat compared to dietary lipid. Consequently understanding the lipidome during induced DNL may provide insight into potential biomarkers of DNL that could be clinically relevant in those at risk of ...

The highly toxic heavy metal Cadmium (Cd) is widely spread in the environment and could exert estrogen-like activity in tissues including breast. Previous studies demonstrated that Cd binds to estrogen receptor α positive (ERα+) breast cancer (BC) cells. In this new study, we evaluated effects of Cd on both ERα+ and ERα negative (ERα-) BC models with the aim to further characterize the mechanisms involved in Cd-related BC carcinogenesis. Specifically, ...